A group of neuropharmacologists from the University of Florida gave a scientific explanation for the morning ritual (which is also repeated during the day): specific neurotransmitters involved, like this
A group of neuropharmacologists from the University of Florida has provided a scientific explanation for the morning ritual of millions of smokers around the world who start their day with a cigarette after drinking coffee and that during the day they often follow the classic cup with a fumatina, an addiction that once turned bars into Soho smokehouses.
Lead authors Roger Papke and Charles Stoke suspected that the underlying behavior was not just a psychological connection, but a precise neurochemical cause and indeed in the September issue of the journal Neuropharmacology has published a study sponsored by National Institutes of Health Use (NIH) where they found it two compounds of coffee they act directly on some the brain’s nicotinic receptors that in smokers they become hypersensitized after a night of abstinence, since apparently one cannot smoke during sleep. Moreover, although the most marked phenomenon upon awakening, this combination always presents itself, because these components of coffee still act on nicotinic acetylcholine receptors. But not all coffees do it the same way: green coffee beans from the Congofor example, three times stronger (from this point of view) than for dark roasted coffee, i.e. that of the classic Italian espresso.
A nicotine booster
For many smokers, the first cigarette of the day is the best because it breaks the nocturnal withdrawal, but because it’s even more satisfying after a cup of coffee? To improve the first cigarette not caffeine
, but another aromatic compound of coffee known as n-MP, an acronym for n-methylpyridine that acts on α4β2 nicotinic acetyl-cholinergic receptors in the brain, which in addition to being involved in addiction are also linked to attention, mental health, movement control. American researchers were able to find out because they worked in a neuropharmacology department and used the so-called technique voltage spike which analyzes the electrical activity of individual brain cells in response to different types of stimuli. The study was carried out both in situations with smoking abstinence and normal consumption and it was seen that the activity of nicotine receptors underwent a so-called PAM effect (positive allosteric modulation), which was positively modulated, resolving the morning abstinence situation more quickly and with greater totality and in general increased the activity of nicotine by reducing the desensitization of nicotine receptors, that is, by strengthening them and making the cigarette more appreciated.
With green coffee beans, the WFP-dependent responses were three times greater than for dark coffee, which partially loses another component of the coffee in the roasting process: choline. This vitamin-like food compound is important for brain function, especially during development, and, as American researchers have now discovered, also activates the α7 nicotinic receptor. therefore likely to also cholinewhich is also involved in mental health, plays an important role in abstinence from smoking is improved by coffee. The results of this study, the authors conclude, provide a new neuropharmacological basis on which behavioral scientists will be able to find new solutions to smoking cessation.
September 16, 2022 (change September 16, 2022 | 17:25)
© REPRODUCTION RESERVED